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Two hundred patients completed a 4-week, single-blind, placebo baseline period, with 134 fulfilling selection criteria and then randomized to tizanidine or placebo.
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In other words, if this single RCT had been rated at 5 out of 11 and then excluded from the analysis then the result of the meta-analysis would have been negative.
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Los hallazgos presentados en reuniones generalmente se consideran preliminares hasta que se publiquen en una revista revisada por profesionales.
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Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice.
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The Cmax and AUC of tizanidine increased by 7-fold and 10-fold, respectively.
Persons who have been taking Tizanidine in large doses over a long period of time will experience severe withdrawal symptoms if they abruptly stop using this medication.
It is part of a larger evidence review commissioned by the American Pain Society and the American College of Physicians to guide recommendations for management of low back pain ().
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Its called the hygiene hypothesis.
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Human trials are messy. It is impossible to make them rigorous in ways that are comparable to laboratory experiments.
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Instruct patients to inform their physicians or pharmacists when they start or stop taking any medication because of the risks associated with interaction between Zanaflex and other medicines.
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Changes in the antibody titers after improvement with immunotherapy will be useful to support this view.
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